pI: 7.2366 |
Length (AA): 192 |
MW (Da): 22020 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 191 | 1fzq (A) | 3 | 177 | 34.00 | 0 | 1 | 1.44 | -1.93 |
22 | 191 | 1m2o (B) | 25 | 190 | 62.00 | 0 | 1 | 1.77 | -2.16 |
8 | 191 | 1f6b (A) | 13 | 197 | 49.00 | 0.00000000011 | 1 | 1.61243 | -1.44 |
22 | 191 | 1m2o (B) | 25 | 190 | 62.00 | 0 | 1 | 1.69822 | -1.42 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Ring, Sporozoite, Female Gametocyte, Male Gametocyte. | Otto TD PlasmoDB Zanghi G Lasonder E |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Ortholog group members (OG5_127331)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G62560 | Ras-related small GTP-binding family protein |
Arabidopsis thaliana | AT1G56330 | GTP-binding protein SAR1B |
Arabidopsis thaliana | AT4G02080 | GTP-binding protein SAR1A |
Babesia bovis | BBOV_II004300 | small GTP-binding protein sar1 |
Brugia malayi | Bm1_36820 | GTP-binding protein SAR1 |
Caenorhabditis elegans | CELE_ZK180.4 | Protein SAR-1 |
Cryptosporidium hominis | Chro.70265 | small GTP-binding protein sar1 |
Cryptosporidium parvum | cgd7_2330 | SAR1-like small GTpase |
Dictyostelium discoideum | DDB_G0272296 | ARF/SAR superfamily protein |
Drosophila melanogaster | Dmel_CG7073 | Sar1 ortholog (S. cerevisiae) |
Echinococcus granulosus | EgrG_000100200 | GTP binding protein SAR1b |
Entamoeba histolytica | EHI_075210 | GTP-binding protein |
Entamoeba histolytica | EHI_031410 | GTP-binding protein |
Entamoeba histolytica | EHI_075040 | GTP-binding protein |
Echinococcus multilocularis | EmuJ_000100200 | GTP binding protein SAR1b |
Giardia lamblia | GL50803_7569 | GTP-binding protein Sar1 |
Homo sapiens | ENSG00000152700 | secretion associated, Ras related GTPase 1B |
Homo sapiens | ENSG00000079332 | secretion associated, Ras related GTPase 1A |
Leishmania braziliensis | LbrM.05.0030 | ras-like small GTPases, putative |
Leishmania donovani | LdBPK_050030.1 | ras-like small GTPases, putative |
Leishmania infantum | LinJ.05.0030 | ras-like small GTPases, putative |
Leishmania major | LmjF.05.0030 | ras-like small GTPases, putative |
Leishmania mexicana | LmxM.05.0030 | small GTP-binding protein, putative |
Loa Loa (eye worm) | LOAG_01165 | hypothetical protein |
Mus musculus | ENSMUSG00000020386 | SAR1 gene homolog B (S. cerevisiae) |
Mus musculus | ENSMUSG00000020088 | SAR1 gene homolog A (S. cerevisiae) |
Neospora caninum | NCLIV_052070 | hypothetical protein |
Oryza sativa | 4352510 | Os12g0560300 |
Oryza sativa | 4326797 | Os01g0338000 |
Oryza sativa | 4327708 | Os01g0254000 |
Oryza sativa | 4340541 | Os06g0225000 |
Plasmodium berghei | PBANKA_0718800 | small GTP-binding protein sar1, putative |
Plasmodium falciparum | PF3D7_0416800 | small GTP-binding protein sar1 |
Plasmodium knowlesi | PKNH_0509200 | small GTP-binding protein sar1, putative |
Plasmodium yoelii | PY04367 | small GTP-binding protein |
Saccharomyces cerevisiae | YPL218W | Arf family GTPase SAR1 |
Schistosoma japonicum | Sjp_0104110 | ko:K07954 SAR1B, putative |
Schistosoma mansoni | Smp_073590 | GTP-binding protein-like protein |
Schmidtea mediterranea | mk4.020490.00 | GTP-binding protein-like protein |
Schmidtea mediterranea | mk4.002137.04 | GTP-binding protein-like protein |
Trypanosoma brucei gambiense | Tbg972.5.6040 | ADP-ribosylation factor, putative |
Trypanosoma brucei | Tb927.5.4500 | ras-like small GTPase, putative |
Trypanosoma brucei | Tb05.5K5.150 | small GTP-binding protein, putative |
Trypanosoma congolense | TcIL3000_0_58560 | small GTP-binding protein, putative |
Trypanosoma congolense | TcIL3000_5_5190 | ADP-ribosylation factor, putative |
Trypanosoma cruzi | TcCLB.509539.50 | small GTP-binding protein, putative |
Toxoplasma gondii | TGME49_215060 | small GTP-binding protein sar1, putative |
Theileria parva | TP04_0542 | GTP-binding protein, putative |
Trichomonas vaginalis | TVAG_222520 | ADP-ribosylation factor, arf, putative |
Trichomonas vaginalis | TVAG_157300 | ADP-ribosylation factor, arf, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.5.4500 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.4500 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.4500 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.5.4500 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_ZK180.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_ZK180.4 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_ZK180.4 | Caenorhabditis elegans | sterile | wormbase |
YPL218W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_215060 | Toxoplasma gondii | Probably essential | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.2